Department of Pharmacology & Toxicology Seminar Series

UAHS Memo

Department of Pharmacology & Toxicology Seminar Series

Tuesday, Dec. 10, 2019

4 p.m.

Health Sciences Innovation Building, Room 880

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Alexis Rohou, PhD

Scientist (Technology), Department of Structural Biology, Genentech


Supporting Drug Discovery and Research with cryoEM


Cryogenic electron microscopy (cryoEM) can solve the structures of proteins bound by small or large molecules even when crystallization of the protein is impossible. This has led Genentech and other large pharmaceutical discovery groups to invest in cryoEM in order to complement other structural biology techniques and better support drug discovery efforts.

I will give an overview of our technology development efforts in the cryoEM space, particularly centered around software, and I will illustrate how cryoEM enables drug discovery and biological research, using as examples a set of structures of ion channels of clinical interest.

Host: Chris Zerio
David Bishop
bishop@pharmacy.arizona.edu

 

Alexis Rohou CV: