Department of Pharmacology & Toxicology Seminar Series
Tuesday, Dec. 10, 2019
Health Sciences Innovation Building, Room 880
Alexis Rohou, PhD
Scientist (Technology), Department of Structural Biology, Genentech
Supporting Drug Discovery and Research with cryoEM
Cryogenic electron microscopy (cryoEM) can solve the structures of proteins bound by small or large molecules even when crystallization of the protein is impossible. This has led Genentech and other large pharmaceutical discovery groups to invest in cryoEM in order to complement other structural biology techniques and better support drug discovery efforts.
I will give an overview of our technology development efforts in the cryoEM space, particularly centered around software, and I will illustrate how cryoEM enables drug discovery and biological research, using as examples a set of structures of ion channels of clinical interest.
Host: Chris Zerio
Alexis Rohou CV: